Must-Start Running Backs

Christian McCaffrey remains the clear top option with a projected 29.4 PPR points as San Francisco takes on Tennessee. The 49ers offense is firing, and the Titans defense has repeatedly struggled to contain elite playmakers—setting up McCaffrey for another heavy production week.

De'Von Achane is a strong play against Pittsburgh's porous run defense. Jahmyr Gibbs belongs in lineups as Detroit faces a Rams defense bleeding chunk plays on the ground. James Cook brings substantial upside as Buffalo travels to New England, which has consistently allowed opposing running backs to produce.

Top Quarterback Plays

Lamar Jackson headlines the QB starts with a 21-point projection against Cincinnati. He's surging while the Bengals defense has crumbled. Dak Prescott, Matthew Stafford, and Jalen Hurts round out the elite options in matchups against Minnesota, Detroit, and Las Vegas respectively.

Wide Receivers and Tight Ends

Puka Nacua is a must-start for the Rams with a 21.2 PPR projection in a high-volume clash with Detroit. Ja'Marr Chase is another tier-one option as Cincinnati attacks Baltimore's secondary. Amon-Ra St. Brown should stay locked in when the Lions visit Los Angeles.

Trey McBride enters Week 15 as a top tight end play with a 14.7 PPR projection. Arizona faces Houston, which has struggled defending his position, and McBride has been a reliable red-zone target.

Sleepers Worth Targeting

Breece Hall is a strong consideration as the Jets face Jacksonville. Hall has delivered steady production and could see increased touches against a Jaguars run defense showing vulnerability. Bucky Irving of Tampa Bay at Atlanta profiles as quality sleeper material with flex value in deeper formats.

At wide receiver, Rashid Shaheed deserves attention when New Orleans faces Carolina. Shaheed continues stretching the field and could exploit a Panthers secondary that has hemorrhaged explosive plays. Troy Franklin of Denver is another sleeper to monitor as the Broncos meet Green Bay—he's been involved in key moments and fits as a WR3 or flex option.

Jake Ferguson of Dallas is in play at Minnesota. The tight end has been a dependable piece of the Cowboys passing game and should stay involved.

For deeper streaming, Trevor Lawrence carries upside as Jacksonville takes on the Jets, while Prescott at Minnesota remains steady with likely heavy passing volume.

Players to Avoid

Deebo Samuel leads the avoid list. He hasn't produced to expectations, his involvement in the 49ers offense remains inconsistent, and his drops make him risky even in a decent matchup.

Darnell Mooney enters a brutal Denver matchup with fluctuating targets and limited production making him a shaky play.

Dallas Goedert belongs in the fade category—injuries have plagued him and his tight end production has been inconsistent week-to-week. Minnesota offers little relief.

Kareem Hunt is a bust candidate. He continues splitting carries without showing dependable efficiency, and facing the Chargers defense doesn't help.

Amon-Ra St. Brown warrants caution despite his usual consistency. The Rams have been strong against opposing receivers, and his volume or efficiency could dip.

Tua Tagovailoa is another fade. The Dolphins quarterback has been inconsistent, and Pittsburgh's defense—which has challenged opposing quarterbacks—makes him a risky start.